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品質設計開発学分野│京都大学 大学院 農学研究科 農学専攻

Laboratory of Food Quality Design and Development Division of Agronomy and Horticultural Science Graduate School of Agriculture, Kyoto University

研究業績

  • A vacuolar sorting receptor-independent sorting mechanism for storage vacuoles in soybean seeds.

    Maruyama N, Matsuoka Y, Yokoyama K, Takagi K, Yamada T, Hasegawa H, Terakawa T, Ishimoto M.

    Scientific Reports 8, 1108 (2018).

  • Cloning, molecular analysis, and developmental expression of 3 oleosin cDNA isoforms in coconut (Cocos nucifera L.).

    Vargas AG, Cabanos C, Garcia RN, Maruyama N, Tecson-Mendoza EM.

    The Journal of Horticultural Science & Biotechnology (2017) Aug, 1-9.

  • Identification and characterization  of GmPDIL7, a soybean ER membrane-bound protein disulfide isomerase family  protein.

    Okuda A, Matsusaki M, Masuda T, Urade R.

    FEBS J 284, 414-428 (2017).

  • Measurement of specific IgE antibodies to Ses i 1  improves the diagnosis of sesame allergy.

    Maruyama N, Nakagawa T, Ito K, Cabanos C, Borres MP, Movérare R, Tanaka A, Sato S, Ebisawa M.

    Clinical & Experimental Allergy 46, 163-171 (2016).

  • Deposition mode of transforming growth factor-beta expressed in transgenic rice seed.

    Takaiwa F, Yang L, Maruyama N, Wakasa Y, Ozawa K.

    Plant Cell Reports 35, 2461-2473 (2016).

  • Clinical utility of recombinant allergen components in diagnosing buckwheat allergy.

    Maruyama N, Sato S, Yanagida N, Cabanos C, Ito K, Borres MP, Movérare R, Tanaka A, Ebisawa M.

    The Journal of Allergy and Clinical Immunology: In Practice 4, 322-323 (2016).

  • Cooperative protein folding by two protein thiol disulfide oxidoreductases and Ero1 in soybean.

    Matsusaki M, Okuda A, Masuda T, Koishihara K, Mita R, Iwasaki K, Hara K, Naruo Y, Hirose A, Tsuchi Y, Urade R

    Plant Physiol 170, 774-789 (2016).

  • Preliminary X-ray analysis of the binding domain of the soybean vacuolar sorting receptor complexed with a sorting determinant of a seed storage protein.

    Maruyama N, Goshi T, Sugiyama S, Niiyama M, Adachi H, Takano K, Murakami S, Inoue T, Mori Y, Matsumura H, Mikami B

    Acta Crystallogr F Struct Biol Commun 71, 132-135 (2015).

  • H-Ferritin Is Preferentially Incorporated by Human Erythroid Cells through Transferrin Receptor 1 in a Threshold-Dependent Manner.

    Sakamoto S, Kawabata H, Masuda T, Uchiyama T, Mizumoto C, Ohmori K, Koeffler HP, Kadowaki N, Takaori-Kondo A

    PLoS One 10, e0139915 (2015).

  • Soybean Ferritin Forms an Iron-Containing Oligomer in Tofu Even after Heat Treatment.

    Masuda T

    J Agric Food Chem 63, 8890-8895 (2015).

  • Expression and characterization of protein disulfide isomerase family proteins in bread wheat.
    Kimura S, Higashino Y, Kitao Y, Masuda T, Urade R
    BMC Plant Biol 15, 460 (2015).
  • The iron content and ferritin contribution in fresh, dried, and toasted nori, Pyropia yezoensis.
    Masuda T, Yamamoto A, Toyohara H
    Biosci Biotechnol Biochem 79, 74-81 (2015).

  • Crystal structure of class III chitinase from pomegranate provides the insight into its metal storage capacity.
    Masuda T, Zhao G, Mikami B
    Biosci Biotechnol Biochem 79, 45-50 (2015).

  • Knockdown of the 7S globulin subunits shifts distribution of nitrogen sources to the residual protein fraction in transgenic soybean seeds.
    Yamada T, Mori Y, Yasue K, Maruyama N, Kitamura K, Abe J
    Plant Cell Rep 33,1963-1976 (2014).

  • Stable accumulation of seed storage proteins containing vaccine peptides in transgenic soybean seeds.
    Maruyama N, Fujiwara K, Yokoyama K, Cabanos C, Hasegawa H, Takagi K, Nishizawa K, Uki Y, Kawarabayashi T, Shouji M, Ishimoto M, Terakawa T
    J Biosci Bioeng 118, 441-447 (2014).

  • Development of a novel transgenic rice with hypocholesterolemic activity via high-level accumulation of the α' subunit of soybean β-conglycinin.
    Cabanos C, Kato N, Amari Y, Fujiwara K, Ohno T, Shimizu K, Goto T, Shimada M, Kuroda M, Masuda T, Takaiwa F, Utsumi S, Nagaoka S, Maruyama N
    Transgenic Res 23, 609-620 (2014).

  • Differential expression and elution behavior of basic 7S globulin among cultivars under hot water treatment of soybean seeds.
    Fujiwara K, Cabanos C, Toyota K, Kobayashi Y, Maruyama N
    J Biosci Bioeng 117, 742-748 (2014).

  • The crystal structure of a crustacean prophenoloxidase provides a clue to understanding the functionality of the type 3 copper proteins.
    Masuda T, Momoji K, Hirata T, Mikami B
    FEBS J 281, 2659-2673 (2014).

  • Disulfide bond formation activity of soybean quiescin sulfhydryl oxidase.
    Okuda A, Matsusaki M, Higashino Y, Masuda T, Urade R
    FEBS J 281, 5341-5355 (2014).

  • Degradation of β-conglycinin β-homotrimer by papain: independent occurrence of limited and extensive proteolysis.
    Shutov AD, Rudakova AS, Rudakov SV, Kakhovskaya IA, Schallau AA, Wilson KA, Maruyama N
    Biosci Biotechnol Biochem 77, 2082-2086 (2013).

  • Purification, crystallization and preliminary crystallographic analysis of soybean mature glycinin A1bB2.
    Prak K, Mikami B, Itoh T, Fukuda T, Maruyama N, Utsumi S
    Acta Crystallogr Sect F Struct Biol Cryst Commun 69, :937-941 (2013).

  • Modification of solubility and heat-induced gelation of amaranth 11S globulin by protein engineering.
    Carrazco-Peña L, Osuna-Castro JA, De León-Rodríguez A, Maruyama N, Toro-Vazquez JF, Morales-Rueda JA, Barba de la Rosa AP
    J Agric Food Chem 61, 3509-3516 (2013).

  • Photoaffinity casting of a coumarin flag for rapid identification of ligand-binding sites within protein.
    Morimoto S, Tomohiro T, Maruyama N, Hatanaka Y
    Chem Commun (Camb) 49, 1811-1813 (2013).

  • High-level production of lactostatin, a hypocholesterolemic peptide, in transgenic rice using soybean A1aB1b as carrier.
    Cabanos C, Ekyo A, Amari Y, Kato N, Kuroda M, Nagaoka S, Takaiwa F, Utsumi S, Maruyama N.
    Transgenic Res 22, 621-629 (2013).

  • Mass spectrometry based N- and C-terminal sequence determination of a hepatopancreas-type prophenoloxidase from the kuruma prawn, Marsupenaeus japonicus.
    Kuyama H, Masuda T, Nakajima C, Momoji K, Sugawara T, Nishimura O, Hirata T
    Anal Bioanal Chem 405, 2333-2340 (2013).

  • Crystal structure of a major seed storage protein, 11S proglobulin, from Amaranthus hypochondriacus: insight into its physico-chemical properties.
    Tandang-Silvas MR, Cabanos CS, Carrazco Peña LD, De la Rosa AP, Osuna-Castro JA, Utsumi S, Mikami B, Maruyama N
    Food Chem 135, 819-826 (2012).

  • Measurement of Ara h 1-, 2-, and 3-specific IgE antibodies is useful in diagnosis of peanut allergy in Japanese children.
    Ebisawa M, Movérare R, Sato S, Maruyama N, Borres MP, Komata T
    Pediatr Allergy Immunol 23, 573-581 (2012).

  • Limited proteolysis regulates massive degradation of glycinin, storage 11S globulin from soybean seeds: an in vitro model.
    Shutov A, Rudakova A, Rudakov S, Kakhovskaya I, Schallau A, Maruyama N, Wilson K
    J Plant Physiol 169, 1227-1233 (2012).

  • Identification and characterization of a ferritin gene and its product from the multicellular green alga Ulva pertusa.
    Morimoto S, Masuda T, Sugihara I, Toyohara H
    Biosci Biotechnol Biochem 76, 1913-1919 (2012).

  • A novel strategy of natural plant ferritin to protect DNA from oxidative damage during iron oxidation.
    Liao X, Lv C, Zhang X, Masuda T, Li M, Zhao G
    Free Radic Biol Med 53, 375-382 (2012).

  •  The extension peptide of plant ferritin from sea lettuce contributes to shell stability and surface hydrophobicity.
    Masuda T, Morimoto S, Mikami B, Toyohara H
    Protein Sci 21, 786-796 (2012).
  • A novel type of prophenoloxidase from the kuruma prawn Marsupenaeus japonicus contributes to the melanization of plasma in crustaceans.
    Masuda T, Otomo R, Kuyama H, Momoji K, Tonomoto M, Sakai S, Nishimura O, Sugawara T, Hirata T
    Fish Shellfish Immunol 32, 61-68 (2012).

  • Molecular design of seed storage proteins for enhanced food physicochemical properties.
    Tandang-Silvas MR, Tecson-Mendoza EM, Mikami B, Utsumi S, Maruyama N.
    Annu Rev Food Sci Technol 2, 59-73 (2012).

  • Crystal structure of the major peanut allergen Ara h 1.
    Cabanos C, Urabe H, Tandang-Silvas MR, Utsumi S, Mikami B, Maruyama N
    Mol Immunol 49, 115-123 (2011).

  • Expression and purification of peanut oleosins in insect cells.
    Cabanos C, Katayama H, Tanaka A, Utsumi S, Maruyama N
    Protein J 30, 457-463 (2011).

  • The development of transgenic crops to improve human health by advanced utilization of seed storage proteins.
    Maruyama N, Mikami B, Utsumi S
    Biosci Biotechnol Biochem 75, 823-828 (2011). Review.

  • Chitinase III in pomegranate seeds (Punica granatum Linn.): a high-capacity calcium-binding protein in amyloplasts.
    Yang H, Zhang T, Masuda T, Lv C, Sun L, Qu G, Zhao G
    Plant J 68, 765-776 (2011).

  • High-capacity calcium-binding chitinase III from pomegranate seeds (Punica granatum Linn.) is located in amyloplasts.
    Lv C, Masuda T, Yang H, Sun L, Zhao G.

    Plant Signal Behav 6, 1963-1965 (2011). Review.
  • Crystallization and preliminary X-ray analysis of the major peanut allergen Ara h 1 core region.
    Cabanos C, Urabe H, Masuda T, Tandang-Silvas MR, Utsumi S, Mikami B & Maruyama N
    Acta Crystallogr Sect F Struct Biol Cryst Commun 66, 1071-1073 (2010).
  • The universal mechanism for iron translocation to the ferroxidase site in ferritin, which is mediated by the well conserved transit site.
    Masuda T, Goto F, Yoshihara T & Mikami B
    Biochem Biophys Res Commun 400, 94-99 (2010).
  • Role of H-1 and H-2 subunits of soybean seed ferritin in oxidative deposition of iron in protein.
    Deng J, Liao X, Yang H, Zhang X, Hua Z, Masuda T, Goto F, Yoshihara T & Zhao G
    J Biol Chem 285, 32075-32086 (2010).
  • Soybean basic 7S globulin: subunit heterogeneity and molecular evolution.
    Shutov AD, Prak K, Fukuda T, Rudakov SV, Rudakova AS, Tandang-Silvas MR, Fujiwara K, Mikami B, Utsumi S & Maruyama N
    Biosci Biotechnol Biochem 74,1631-1634 (2010).
  • Expression, purification and preliminary crystallization of amaranth 11S proglobulin seed storage protein from Amaranthus hypochondriacus L.
    Tandang-Silvas MR, Carrazco-Pena L, Barba de la Rosa AP, Osuna-Castro JA, Utsumi S, Mikami B & Maruyama N
    Acta Crystallogr Sect F Struct Biol Cryst Commun 66, 919-922 (2010).
  • Development of transgenic rice containing a mutated beta subunit of soybean beta-conglycinin for enhanced phagocytosis-stimulating activity.
    Motoyama T, Amari Y, Tandang-Silvas MR, Cabanos C, Kimura A, Yoshikawa M, Takaiwa F, Utsumi S & Maruyama N
    Peptides 31, 1245-1250 (2010).
  • Expression, purification, cross-reactivity and homology modeling of peanut profilin.
    Cabanos C, Tandang-Silvas MR, Odijk V, Brostedt P, Tanaka A, Utsumi S & Maruyama N
    Protein Expr Purif 73, 36-45 (2010).
  • Conservation and divergence on plant seed 11S globulins based on crystal structures.
    Tandang-Silvas MR, Fukuda T, Fukuda C, Prak K, Cabanos C, Kimura A, Itoh T, Mikami B, Utsumi S & Maruyama N
    Biochim Biophys Acta 1804, 1432-1442 (2010).
  • Carbohydrate moieties contribute significantly to the physicochemical properties of french bean 7s globulin phaseolin.
    Kimura A, Tandang-Silvas MR, Fukuda T, Cabanos C, Takegawa Y, Amano M, Nishimura S, Matsumura Y, Utsumi S & Maruyama N
    J Agric Food Chem 58, 2923-2930 (2010).
  • Co-expression of alpha' and beta subunits of beta-conglycinin in rice seeds and its effect on the accumulation behavior of the expressed proteins.
    Motoyama T, Okumoto Y, Tanisaka T, Utsumi S & Maruyama N
    Transgenic Res 19, 819-827 (2010).
  • A novel EP-involved pathway for iron release from soya bean seed ferritin.
    Fu X, Deng J, Yang H, Masuda T, Goto F, Yoshihara T & Zhao G
    Biochem J 427, 313-321 (2010).
  • Crystal structure of plant ferritin reveals a novel metal binding site that functions as a transit site for metal transfer in ferritin.
    Masuda T, Goto F, Yoshihara T & Mikami B
    J Biol Chem 285, 4049-4059 (2010).
  • Aggregation of proteins having Golgi apparatus determinant induces large globular structures derived from the endoplasmic reticulum in plant seed cells.
    Maruyama N, Okuda E, Tatsuhara M & Utsumi S
    FEBS Lett 582,1599-1606 (2008).
  • Construction of homo- and heteropolymers of plant ferritin subunits using an in vitro protein expression system.
    Masuda T, Goto F, Yoshihara T, Ezure T, Suzuki T, Kobayashi S, Shikata M & Utsumi S
    Protein Expr Purify 56, 237-246 (2007).
  • The C-terminal region of α′subunit of soybean β-conglycinin contains two types of vacuolar sorting determinants.
    Nishizawa K, Maruyama N & Utsumi S
    Plant Mol Biol 62, 111-125 (2006).
  • Multiple vacuolar sorting determinants sxist in soybean 11S globulin.
    Maruyama,N., Loeng CM, Tatsuhara M, Sawada M, Ishimoto M & Utsumi S
    Plant Cell 18, 1253-1273 (2006).